Product
|
FGF-acidic, Mouse
|
Cat#
|
101-19-51C
|
Sequence
|
FNLPLGNYKK PKLLYCSNGG HFLRILPDGT VDGTRDRSDQ
HIQLQLSAES AGEVYIKGTE TGQYLAMDTE GLLYGSQTPN
EECLFLERLE ENHYNTYTSK KHAEKNWFVG LKKNGSCKRG
PRTHYGQKAI LFLPLPVSSD
|
Unit/Weight
|
1 mg
|
Unit Price
|
$618.00
|
Description
|
Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers.
Recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) produced in E. coli is a single non-glycosylated polypeptide chain containing 140 amino acids. A fully biologically active molecule, rmFGF-acidic has a molecular mass of 15.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
|
Molecular Weight
|
15.8 kDa, observed by reducing SDS-PAGE.
|
Purity
|
> 95% by SDS-PAGE and HPLC analyses.
|
Storage
|
Lyophilized recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmFGF-acidic should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
|
|