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Product
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FGF-10, His, Human
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Cat#
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101-19-47C
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Sequence
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MNHKVHHHHH HMDDDDKMLG QDMVSPEATN SSSSSFSSPS
SAGRHVRSYN HLQGDVRWRK LFSFTKYFLK IEKNGKVSGT
KKENCPYSIL EITSVEIGVV AVKAINSNYY LAMNKKGKLY
GSKEFNNDCK LKERIEENGY NTYASFNWQH NGRQMYVALN
GKGAPRRGQK TRRKNTSAHF LPMVVHS
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Unit/Weight
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1 mg
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Unit Price
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$1493.00
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Description
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Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares the homolog and receptor FGFR2-IIIb with KGF. However, unlike KGF which induces the proliferation and differentiation of various epithelial cells, FGF-10 is an essential factor for the budding and branching morphogenesis during the multi-organ development via the instructive mesenchymal-epithelial interactions. FGF-10 is crucial for lung and limb development, and is regulated by Shh during early development.
Recombinant human Fibroblast Growth Factor-10 (rhFGF-10) with N-terminal His-tag produced in E. coli is a single non-glycosylated polypeptide chain containing 187 amino acids. A fully biologically active molecule, rhFGF-10 has a molecular mass of 21.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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21.4 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE analysis.
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Storage
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Lyophilized recombinant human Fibroblast Growth Factor-10 (rhFGF-10) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-10 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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