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Product
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FGF-8, Human
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Cat#
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101-19-35B
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Sequence
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MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS
GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG
AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL
QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG
HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
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Unit/Weight
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50 μg
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Unit Price
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$152.00
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Description
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Fibroblast Growth Factor-8 (FGF-8) is a heparin-binding growth factor of the FGF family. There are 4 known forms of FGF8 produced by alternative splicing: FGF8a, FGF-8b, FGF-8e and FGF-8f. The human and mouse FGF8b are identical of aa sequences. FGF-8 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF-8 is required for normal brain, eye, ear and limb development during embryogenesis. It is also required for normal development of the gonadotropin- releasing hormone (GnRH) neuronal system.
Recombinant human Fibroblast Growth Factor-8 (rhFGF-8) produced in E. coli is a single non-glycosylated polypeptide chain containing 194 amino acids. A fully biologically active molecule, rhFGF-8 has a molecular mass of 22.5kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at Pepmic.
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Molecular Weight
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22.5kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE and HPLC analyses.
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Storage
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Lyophilized recombinant human Fibroblast Growth Factor-8 (rhFGF-8) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-8 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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