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Product
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FGF-13, Human
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Cat#
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101-19-22C
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Sequence
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MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK
NKLNVFSRVK LFGSKKRRRR RPEPQLKGIV TKLYSRQGYH
LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK
LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY
RQQQSGRGWY LGLNKEGEIM KGNHVKKNKP AAHFLPKPLK
VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS
HNEST
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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Fibroblast growth factor 13 (FGF13) is a new member of the fibroblast growth factor (FGF) family. They possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-13 was initially identified as FHF2 along with three other FHF factors, FHF1/FGF12, FHF3/FGF-11 and FHF4/FGF14 that comprise a unique intracellular FGF (iFGF) subfamily expressed throughout the developing and adult nervous system. Human FGF13 stimulated the phenotypic differentiation of cortical neurons. FGF13 interacts with voltage-gated sodium channel alpha subunit, and colocalizes at the nodes of Ranvier of dorsal root axons. The mechanism of action for FGF13 in neural development has not been described in detail.
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Molecular Weight
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Approximately 27.6 kDa, a single non-glycosylated polypeptide chain containing 245 amino acids.
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Purity
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> 95 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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