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Product
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FGF-21, Human
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Cat#
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101-19-08A
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Sequence
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HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT
VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP
EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP
GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA
S
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Unit/Weight
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20 μg
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Unit Price
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$128.00
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Description
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Fibroblast growth factor 21 (FGF21) belongs to the large FGF family which has at least 23 members. All FGF family members are heparin binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes.
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Molecular Weight
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Approximately 19.4 kDa, a single non-glycosylated polypeptide chain containing 181 amino acids.
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Purity
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> 96 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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