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Product
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Human PAI-1
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Cat#
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101-5-06A
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Sequence
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His-Tag sequence not included: VHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVA SVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDE ISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWV KTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFH KSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAP YEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPL ENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTA VIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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Plasminogen Activator Inhibitor 1 (PAI-1) is a serine protease inhibitor which can exist either in an active inhibitory conformation or in an inactive or latent conformation. PAI-1 is produced mainly by the endothelium but is also secreted by other tissue types including adipose tissue. PAI-1 is the principal inhibitor of tissue plasminogen activator and urokinase, therefore inhibiting fibrinolysis. Increased levels of PAI-1 have been linked with various conditions including cardiovascular disease, thrombosis, insulin resistance and obesity. Recombinant PAI-1 comprises a 379 amino acid fragment (24-402) corresponding to the mature PAI-1 protein and is expressed in E. coli with an amino-terminal hexahistidine tag.
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Molecular Weight
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47.23 kDa
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Purity
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Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA
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Storage
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Store at -20°C. Product is guaranteed one year from the date of shipment.
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