|
Product
|
Ambra1 Antibody
|
|
Cat#
|
100-3-02A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$311.00
|
|
Species Reactivity
|
H, M
|
|
Tested Application(s)
|
E, WB, IHC
|
|
Brief Description
|
Pepmic offers Ambra1 Antibody product having catalog no is 4557
|
|
Specific Description
|
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death . Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
|
|
Storage
|
Ambra1 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
|
|