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Product
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Thymus Chemokine??/CXCL7, Rat
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Cat#
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101-27-230C
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Sequence
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IELRCRCTNT LSGIPLNSIS RVNVFRPGAH CDNVEVIATL
KNGKEVCLDP TAPMIKKIVK KI
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Unit/Weight
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1 mg
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Unit Price
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$1343.00
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Description
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Thymus Chemokine‑1, also called Chemokine (C-X-C motif) ligand 7 (CXCL7) , is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, Thymus Chemokine‑1 has been shown to bind CXCR-2 and be a chemoattractant forneutrophils and play a role in their activation. Although CTAP-III, β-TG and PBP represent amino-terminal extended variants of Thymus Chemokine‑1 and possess the same CXC chemokine domains, these proteins do not exhibit Thymus Chemokine‑1 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III mask the critical ELR receptor binding domain that is exposed on Thymus Chemokine‑1 and may account for lack of Thymus Chemokine‑1 activity. Rat CXCL7 shares 72% amino acid sequence identity with mouse CXCL7.
Recombinant rat Thymus Chemokine‑1/ CXCL7 produced in CHO cells is a polypeptide chain containing 62 amino acids. A fully biologically active molecule, rrThymus Chemokine‑1/CXCL7 has a molecular mass of 9.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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9.8 kDa, observed by reducing SDS-PAGE.
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Purity
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> 97% as analyzed by SDS-PAGE and HPLC.
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Storage
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Lyophilized recombinant Rat Thymus Chemokine‑1/CXCL7 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Rat Thymus Chemokine‑1/CXCL7 should be stable up to 1 week at 4°C or up to 3 months at -20°C.
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