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Product
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ENA-78/CXCL5 (5-78aa), Human
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Cat#
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101-27-215C
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Sequence
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AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV
VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN
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Unit/Weight
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1 mg
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Unit Price
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$1293.00
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Description
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Epithelial cellderived neutrophilactivating peptide (ENA78) also known as C-X-C motif chemokine 5(CXCL5), is a small cytokine belonging to the CXC chemokine family. It is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. Expression of CXCL5 has also been observed in eosinophils, and can be inhibited with the type II interferon, IFN-γ. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. Full length CXCL5 (78 aa) is trimmed at the Nterminal end by cathepsin G and chymotrypsin to ENA-74 (74 aa) and ENA-70 (70aa), with the shortened forms showing increased potency relative to full length CXCL5. CXCL5can signal through the CXCR2 receptor.
Recombinant human ENA-78/CXCL5 (5-78a.a.) produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rh ENA-78/CXCL5 (5-78a.a.) has a molecular mass of 8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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8 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE
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Storage
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Lyophilized recombinant human ENA-78/CXCL5 (5-78a.a.) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human ENA-78/CXCL5 (5-78a.a.) should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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