|
Product
|
GCP-2/CXCL6, Human
|
|
Cat#
|
101-27-210A
|
|
Sequence
|
VLTELRCTCL RVTLRVNPKT IGKLQVFPAG PQCSKVEVVA
SLKNGKQVCL DPEAPFLKKV IQKILDSGNK KN
|
|
Unit/Weight
|
5 μg
|
|
Unit Price
|
$32.00
|
|
Description
|
Granulocyte chemotactic protein 2 (GCP-2) also known as Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family. As its former name suggests, GCP-2 is a chemoattractant for neutrophilic granulocytes. Among human CXC chemokines, GCP? is most closely related to ENA?8 (78% amino acid (aa) sequence identity in the mature peptide region and 86% identity in the signal sequence). The structure and sequence of the genes for human GCP? and ENA?8 also exhibit close similarity suggesting the two genes may have originated from a gene duplication. GCP? can signal through the CXCR1 and CXCR2 receptors.
Recombinant human GCP-2/CXCL6 produced in CHO cells is a polypeptide chain containing 72 amino acids. A fully biologically active molecule, rhGCP-2/CXCL6 has a molecular mass of 9 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
|
|
Molecular Weight
|
9 kDa, observed by reducing SDS-PAGE.
|
|
Purity
|
> 98% as analyzed by SDS-PAGE.
|
|
Storage
|
Lyophilized recombinant human GCP-2/CXCL6 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human GCP-2/CXCL6 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
|
|