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Product
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MIP-2/CXCL2, Mouse
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Cat#
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101-27-178B
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Sequence
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AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV
IATLKGGQKVCLDPEAPLVQ KIIQKILNKG KAN
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a mouse macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC) subfamily of chemokines.Similarly to other alpha chemokines, mouse MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the mouse interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
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Molecular Weight
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Approximately 7.8 kDa, a single, non-glycosylated polypeptide chain containing 73 amino acids.
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Purity
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> 97 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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