Product
|
MIP-2/CXCL2, Mouse
|
Cat#
|
101-27-178A
|
Sequence
|
AVVASELRCQ CLKTLPRVDF KNIQSLSVTP PGPHCAQTEV
IATLKGGQKVCLDPEAPLVQ KIIQKILNKG KAN
|
Unit/Weight
|
20 μg
|
Unit Price
|
$152.00
|
Description
|
Macrophage Inflammatory Protein 2 (MIP-2) was originally identified as a heparin binding protein secreted from a mouse macrophage cell line in response to endotoxin stimulation. Based on its protein and DNA sequences, MIP-2 is a member of the alpha (CXC) subfamily of chemokines.Similarly to other alpha chemokines, mouse MIP-2 is a potent neutrophil attractant and activator. MIP-2 and KC can bind the mouse interleukin 8 type B receptor homologue with high affinity. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammation and glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.
|
Molecular Weight
|
Approximately 7.8 kDa, a single, non-glycosylated polypeptide chain containing 73 amino acids.
|
Purity
|
> 97 % by SDS-PAGE and HPLC analyses.
|
Storage
|
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
|
|