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Product
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MDC/CCL22 (69aa), Human
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Cat#
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101-27-148A
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Sequence
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MGPYGANMED SVCCRDYVRY RLPLRVVKHF YWTSDSCPRP
GVVLLTFRDK EICADPRVPWVKMILNKLSQ
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Unit/Weight
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5 μg
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Unit Price
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$32.00
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Description
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Macrophage-Derived/CCL22 Chemokine (MDC) , also known as stimulated T cell chemotactic protein (STCP?), is a CC chemokine initially isolated from clones of monocyteç’¬erived macrophages. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. CCL22 shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. CCL22 has mild chemotactic activity for primary activated T lymphocytes and no chemoattractant activity for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also be involved in certain aspects of activated T lymphocyte physiology, such astrafficking activated T lymphocytes to inflammatory sites. CCL22 interacts with the cell surface chemokine receptor CCR4.
Recombinant Human MDC/CCL22 (69aa) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMDC (69aa) has a molecular mass of 8.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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8.1 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant Human MDC/CCL22 (69aa) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Human MDC/CCL22 (69aa) should be stable up to 1 week at 4°C or up to 3 months at -20°C.
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