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Product
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MCP-1/CCL2, Rat
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Cat#
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101-27-141A
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Sequence
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QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA
VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY
KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT
SMTEN
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Unit/Weight
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5 μg
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Unit Price
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$43.00
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Description
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Chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemotactic protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. CCL2 is implicated in the pathogeneses of several diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis and atherosclerosis. CCL2 is anchored in the plasma membrane of endothelial cells by glycosaminoglycan side chains of proteoglycans. CCL2 is primarily secreted by monocytes, macrophages and dendritic cells. CCL2 can signal through the CCR2 receptor.
Recombinant rat MCP-1/CCL2 produced in HEK293 cells is a polypeptide chain containing 125 amino acids. A fully biologically active molecule, rrMCP-1/CCL2 has a molecular mass of 10-15 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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10~15 kDa, observed by reducing SDS-PAGE.
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Purity
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> 98% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant Rat MCP-1/CCL2 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Rat MCP-1/CCL2 should be stable up to 1 week at 4°C or up to 3 months at -20°C.
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