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Product
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I-309/CCL1, Human
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Cat#
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101-27-130A
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Sequence
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SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL
IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK
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Unit/Weight
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5 μg
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Unit Price
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$48.00
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Description
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Chemokine (C-C motif) ligand 1 (CCL1), also known as I-309, is a small glycoprotein secreted by activated T cells that belongs to the family ofchemokines. Human CCL1 has been assumed to be a homologue of mouse TCA3. While the two proteins share only approximately 42% amino acid sequence identity, both chemokines contain an extra pair of cysteine residues not found in most other chemokines. CCL1 attracts monocytes, NK cells, immature B cells and dendritic cells by interacting with the cell surface chemokine receptor CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
Recombinant Human I-309/CCL1 produced in E.coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-309/CCL1has a molecular mass of 8.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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8.5 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% as analyzed by SDS-PAGE.
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Storage
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Lyophilized recombinant human I-309/CCL1 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, recombinant human I-309/CCL1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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