|
Product
|
HCC‑4/CCL16, Human(CHO-expressed)
|
|
Cat#
|
101-27-105B
|
|
Sequence
|
QPKVPEWVNT PSTCCLKYYE KVLPRRLVVG YRKALNCHLP
AIIFVTKRNR EVCTNPNDDW VQEYIKDPNL PLLPTRNLST
VKIITAKNGQ PQLLNSQ
|
|
Unit/Weight
|
50 μg
|
|
Unit Price
|
$152.00
|
|
Description
|
Human HCC?, also named NCC?and Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). It can signal through the CCR8 and CCR1 receptors, and it is chemotactic towards monocytes and lymphocytes but not neutrophils. HCC-4 is expressed weakly by some lymphocytes, including NK cells, T cells, and some T cell clones. The expression of HCC-4 in monocytes is greatly up-regulated in the presence of IL-10. HCC-4 induces a calcium flux in thp-1 cells that are desensitized prior to the expression of RANTES.
|
|
Molecular Weight
|
12 kDa, observed by reducing SDS-PAGE.
|
|
Purity
|
> 98% as analyzed by SDS-PAGE.
|
|
Storage
|
Lyophilized recombinant human HCC‑4/CCL16 remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human HCC‑4/CCL16 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
|