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Product
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MCP-2/CCL8, Human
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Cat#
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101-27-99A
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Sequence
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QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA
VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP
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Unit/Weight
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5 μg
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Unit Price
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$58.00
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Description
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MCP-2 is a member of the chemokines, a group of 70-80 residue proteins sharing substantial sequence similarity. Within the chemokines, MCP-2 belongs to the CC subfamily, and is a member of the Monocyte Chemoattractant Proteins (MCPs), which includes MCP-1, MCP-2, MCP-3, MCP-4, and MCP-5. MCP-2 shares 60% homology with MCP-1, and both proteins can undergo reversible dimerization. The main receptors of MCP-2 are G-protein coupled receptors CCR1 and CCR5. MCP-2 is a potential target in HIV-1 infected human glial cells as it may play a role in the modulation of viral spread in the brain. Recently, researchers found that mouse MCP-2 is expressed in the skin as a novel agonist of CCR8 and plays a role in eosinophilic inflammation.
Recombinant human MCP-2/CCL8(rhMCP-2) produced in E. coli is a single non-glycosylated polypeptide chain containing 76 amino acids. A fully biologically active molecule, rhMCP-2 has a molecular mass of 8.9kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at Pepmic.
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Molecular Weight
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8.9 kDa, observed by reducing SDS-PAGE.
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Purity
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> 95% by SDS-PAGE analysis.
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Storage
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Lyophilized recombinant human MCP-2/CCL8(rhMCP-2) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhMCP-2 remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
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