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Product
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MIP-3/CCL23, Human
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Cat#
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101-27-31B
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Sequence
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RVTKDAETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR
SIPCSLLESY FETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL
DTRIKTRKN
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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MIP-3/CCL23 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Alternative splicing of the MPIF1 gene results in two mRNAs that encode a short (CK?) and a long (CK?1) isoform of the chemokine. CK? cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CK? (aa 22 120). Additional N terminal processing of the 99 aa residue variant can generate a 75 aa residue CK? (aa 46 120) that is significantly more active than the 99 aa residue variant.
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Molecular Weight
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Approximately 11.4 kDa, a single, non-glycosylated polypeptide chain containing 99 amino acids.
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Purity
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> 97 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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