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Product
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MIP-4/CCL18, Human
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Cat#
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101-27-23B
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Sequence
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AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI
LLTKRGRQIC ADPNKKWVQK YISDLKLNA
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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CCL18, is a novel CC chemokine that is highly homologous to MIP-1?(61% amino acid sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10 and IL-13, and inhibited by IFN-纬. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells, but not monocytes or neutrophils.
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Molecular Weight
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Approximately 7.9 kDa, a single non-glycosylated polypeptide chain containing 69 amino acids.
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Purity
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> 97 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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