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Product
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MIP-1β/CCL4, Human
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Cat#
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101-27-04B
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Sequence
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APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV
VFQTKRSKQV CADPSESWVQ EYVYDLELN
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Unit/Weight
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1 mg
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Unit Price
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$2093.00
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Description
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Both MIP-1 alpha and MIP-1 beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1 alpha and MIP-1 beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1 alpha selectively attracting CD8+ lymphocytes and MIP-1 beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1 alpha and MIP-1 beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and mouse MIP-1 alpha and MIP-1 beta are active on human and mouse hematopoietic cells.
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Molecular Weight
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Approximately 7.8 kDa, a single non-glycosylated polypeptide chain containing 69 amino acids.
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Purity
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> 96 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C. Avoid repeated freeze/thaw cycles.
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