|
Product
|
Human IL-12 beta
|
|
Cat#
|
101-13-171A
|
|
Sequence
|
His-Tag sequence not included: IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTL DQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIW STDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGS SDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMV DAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTW STPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQD RYYSSSWSEWASVPCS
|
|
Unit/Weight
|
0.01 mg
|
|
Unit Price
|
$228.00
|
|
Description
|
Interleukin-12 beta (IL-12 beta) is a cytokine that can act as a growth factor for activated T and NK cells. IL-12 beta enhances the lytic activity of NK/lymphokine-activated killer cells, and stimulates the production of IFN-gamma by resting PBMC. IL-12 beta associates with IL23A to form IL-23, a heterodimeric cytokine which functions in innate and adaptive immunity. Defects in IL12 beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. Recombinant IL-12 beta comprises a 306 amino acid fragment (23-328) corresponding to the mature IL-12 beta chain and is expressed in E. coli with an amino-terminal hexahistidine tag.
|
|
Molecular Weight
|
39.02 kDa
|
|
Purity
|
Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA.
|
|
Storage
|
Store at -20°C. Product is guaranteed one year from the date of shipment.
|