|
Product
|
Human IL-17A
|
|
Cat#
|
101-13-165A
|
|
Sequence
|
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
|
|
Unit/Weight
|
0.025 mg
|
|
Unit Price
|
$228.00
|
|
Description
|
Interleukin-17A (IL-17A or CTLA-8) induces stromal cells to produce proinflammatory cytokines. IL-17A enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. Human, mouse and rat IL-17A show activity on mouse cells. Recombinant Human IL-17A produced in E. coli is a homodimeric non-glycosylated disulfide-linked homodimer containing two 137 amino acid chains with a MW of 31,332 Da. The recombinant protein corresponds to full-length IL-17A and has cytokine production activity on mouse cells.
|
|
Molecular Weight
|
31332 Da
|
|
Purity
|
Purity > 98% as determined by reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
|
|
Storage
|
Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
|
|