|
Product
|
Human IL-17A/F
|
|
Cat#
|
101-13-164A
|
|
Sequence
|
IL17A: MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA; IL-17F: MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
|
|
Unit/Weight
|
0.025 mg
|
|
Unit Price
|
$228.00
|
|
Description
|
Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A, i.e. inducing production of a variety of chemokines in addition to airway neutrophilia. In regard to these functions, IL-17AF has less activity than the IL-17A homodimer but greater activity than the IL-17F homodimer. Human and rat IL-17AF both show activity on mouse cells. Recombinant human IL-17AF produced in E.coli is a heterodimeric non-glycosylated polypeptide comprised of one monomeric subunit each of human IL-17A and human IL-17F. The dimer consists of 271 amino acids, with an approximate molecular weight of 30.7 kDa. The recombinant protein corresponds to full-length IL-17A and IL-17F and has cytokine production activity on mouse cells.
|
|
Molecular Weight
|
30690 Da
|
|
Purity
|
Purity > 98% as determined by reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
|
|
Storage
|
Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
|