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Product
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Human IL-33
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Cat#
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101-13-153A
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Sequence
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His-Tag sequence not included: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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Interleukin 33 (IL-33) is a proimflammatory cytokine belonging to the IL-1 family. IL-33 is cleaved intracellularly, generating an N terminal and a C terminal fragment. The C terminal fragment corresponds to the mature IL-33 protein and mediates its biological effect by interacting with the IL-1 receptor, also known as ST2. Binding of mature IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces the production of associated cytokines, in particular IL-4, IL-5 and IL-13, causing severe pathological changes in mucosal organs. Recombinant interleukin-33 comprises a 159 amino acid fragment (112-270) corresponding to C terminal Interleukin-33 fragment and is expressed in E. coli with an amino-terminal hexahistidine tag.
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Molecular Weight
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22.49 kDa
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Purity
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Purity > 95% as determined by reducing and non-reducing SDS-PAGE, Bradford assay, Western blot and ELISA.
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Storage
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Store at -20°C. Product is guaranteed one year from the date of shipment.
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