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Product
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Mouse EBI-3
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Cat#
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101-13-85A
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Sequence
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MALVALSQPRVQCHASRYPVAVDCSWTPLQAPNSTRSTSFIATYRLGVAT QQQSQPCLQRSPQASRCTIPDVHLFSTVPYMLNVTAVHPGGASSSLLAFV AERIIKPDPPEGVRLRTAGQRLQVLWHPPASWPFPDIFSLKYRLRYRRRG ASHFRQVGPIEATTFTLRNSKPHAKYCIQVSAQDLTDYGKPSDWSLPGQV ESAPHKP
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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Epstein-Barr Virus Induced Gene-3 (EBI-3 or IL27-beta) is a secreted glycoprotein belonging to the hematopoietin receptor family and related to the p40 subunit of IL-12. It was identified by its induced expression in B-lymphocytes in response to Epstein-Barr virus infection. EBI-3 forms heterodimers with p28 to form IL-27 and with p35 to form IL-35. Both IL-27 and IL-35 have anti-inflammatory and regulatory activity. This cytokine can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and has diverse effects on innate immune cells. It synergizes with IL-12 to trigger interferon-gamma production in na飗e CD4 T-cells, and binds to the cytokine receptor WSX-1/TCCR. It also has antitumor and antiangiogenic activity by inducing the production of antiangiogenic chemokines. Recombinant Mouse EBI is a non-glycosylated polypeptide chain consisting of 207 amino acids with a MW of 22.9 kDa.
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Molecular Weight
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22900 Da
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Purity
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Purity > 90% as determined by analytical HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and quantitation on SDS-PAGE against a known standard.
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Storage
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Store at -20C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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