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Product
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Mouse IL-1 beta
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Cat#
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101-13-73A
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Sequence
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VPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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Interleukin-1 beta (IL-1beta) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendritic cells (DCs). IL-1beta and IL-1alpha are two distinct and independently regulated gene products, that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1alpha is cell associated and IL-1beta is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Mouse IL-1 beta is produced in E.coli. Recombinant mouse IL-1? is a non-glycosylated protein, containing 152 amino acids , with a molecular weight of 17.4 kDa.
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Molecular Weight
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17400 Da
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Purity
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Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
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Storage
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Store at -20C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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