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Product
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Mouse Rank Ligand
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Cat#
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101-13-20A
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Sequence
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PAMMEGSWLDVAQRGKPEAQPFAHLTINAASIPSGSHKVTLSSWYHDRGW AKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPTDYLQLMVYVV KTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISIQV SNPSLLDPDQDATYFGAFKVQDID
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Unit/Weight
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0.01 mg
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Unit Price
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$228.00
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Description
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RANK Ligand (RANKL) occurs in 3 forms: cell-bound RANKL, which is expressed by osteoblast lineage cells, soluble RANKL, which is expressed by activated T lymphocytes, and a truncated ectodomain form derived from the cell-bound RANKL, which is enzymatically processed by TACE. All three forms stimulate their specific receptors, TNFRSF11B/OPG and TNFRSF11A/RANK, which are located on osteoclastic and dendritic cells. RANKL is critically involved in osteoclastic function, and in the regulation of specific immunity. Recombinant M-sRANK Ligand is approximately 19.9 kDa and contains 174 amino acids.
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Molecular Weight
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19900 Da
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Purity
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Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
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Storage
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Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
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