|
Product
|
Mouse Sonic Hedgehog
|
|
Cat#
|
101-13-14A
|
|
Sequence
|
MIIGPGRGFG KRRHPKKLTP LAYKQFIPNV AEKTLGASGR YEGKITRNSE RFKELTPNYN PDIIFKDEEN TGADRLMTQR CKDKLNALAI SVMNQWPGVK LRVTEGWDED GHHSEESLHY EGRAVDITTS DRDRSKYGML ARLAVEAGFD WVYYESKAHI HCSVKAENSV AAKSGG
|
|
Unit/Weight
|
0.025 mg
|
|
Unit Price
|
$228.00
|
|
Description
|
Sonic Hedgehog is a member of a small group of secreted proteins that are essential for development in both vertebrates and invertebrates. This cytokine binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Three mammalian hedgehog genes (sonic, desert, Indian) share about 60% homology. Mouse Sonic Hedgehog is 99% homologous to the human gene. Cysteine at position 25 has been substituted with Ile. Mouse SHH is a non-glycosylated polypeptide consisting of 176 amino acids with a MW of 19.8 kDa.
|
|
Molecular Weight
|
19800 Da
|
|
Purity
|
Purity > 97% as determined by reducing and non-reducing SDS-PAGE. Analytical HPLC. Protein Content determined by UV spectroscopy at 280 nm and quantitation on SDS-PAGE against a known standard.
|
|
Storage
|
Store at -20°C. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. We recommend to add a carrier protein (0.1% HSA or BSA) for long term storage.
|