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Product
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BMP-7, Human
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Cat#
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101-15-03B
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Sequence
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STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK
HELYVSFRDL GWQDWIIAPE GYAAYYCEGE CAFPLNSYMN
ATNHAIVQTL VHFINPETVP KPCCAPTQLN AISVLYFDDS
SNVILKKYRN MVVRACGCH
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Unit/Weight
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1 mg
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Unit Price
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$5393.00
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Description
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Human BMP-7 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor ?(TGF-? superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP-7 is synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
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Molecular Weight
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Approximately 15.7 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids.
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Purity
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> 95 % by SDS-PAGE and HPLC analyses.
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Storage
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This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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