|
Product
|
BD-2, Human
|
|
Cat#
|
101-14-03B
|
|
Sequence
|
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
|
|
Unit/Weight
|
1 mg
|
|
Unit Price
|
$2093.00
|
|
Description
|
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ?defensins are distinguished from the ?defensins by the pairing of their three disulfide bonds. To date, four human ?defensins have been identified; BD-1, BD-2, BD-3 and BD-4. ?defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The ?defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. ?defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. ?Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
|
|
Molecular Weight
|
Approximately 4.3 kDa, a single non-glycosylated polypeptide chain containing 41 amino acids.
|
|
Purity
|
> 98 % by SDS-PAGE and HPLC analyses.
|
|
Storage
|
This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
|
|