|
Product
|
TLR5 Antibody
|
|
Cat#
|
100-21-157A
|
|
Unit/Weight
|
100 μg
|
|
Unit Price
|
$311.00
|
|
Species Reactivity
|
H, M
|
|
Tested Application(s)
|
E, WB, ICC
|
|
Brief Description
|
(CT) Toll-like receptor
|
|
Specific Description
|
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-Α and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response (5).
|
|
Storage
|
TLR5 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
|
|