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Product
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IRAK Monoclonal Antibody
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Cat#
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100-21-72A
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Unit/Weight
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100 μg
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Unit Price
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$311.00
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Species Reactivity
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H, M
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Tested Application(s)
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E, WB
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Brief Description
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IL-1-Receptor Associated Kinase
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Specific Description
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Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
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Storage
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IRAK monoclonal antibody can be stored at 4°C, stable for one year.
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