N-terminal Modifications
Chemically synthesized peptides have free N-terminus. Via N-terminal acetylation the charge is removed from the amino terminus of a peptide. Generally, acetyl modification is recommended to make the peptide more closely mimic the charge state in the native protein. In addition this modification stabilizes the resulting peptide, and enhances their ability to resist enzymatic degradation by exopeptidases.

A multitude of N-terminal modifications can be applied by Pepmic’s peptide synthesis experts. Frequently applied N-terminal modifications are listed in the table below.

Name Structure
Acetyl
Formyl
Pyroglutamyl (pGlu)
Fatty acids
Urea
Carbamate
Sulfonamide
Alkylamine